Effects of rosmarinic acid on acetaminophen-induced hepatotoxicity in male Wistar rats

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Acetaminophen Induced Hepatotoxicity in Wistar Rats--A Proteomic Approach.

Understanding the mechanism of chemical toxicity, which is essential for cross-species and dose extrapolations, is a major challenge for toxicologists. Standard mechanistic studies in animals for examining the toxic and pathological changes associated with the chemical exposure have often been limited to the single end point or pathways. Toxicoproteomics represents a potential aid to the toxico...

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Protective effect of Phlomis cancellata hydroalcoholic extract on acute acetaminophen-induced hepatotoxicity in male rats

Background and Aims: Acetaminophen is a common anti-analgesic and antipyretic medication that in high doses leads to liver and kidney necrosis in humans and animals. Phlomis cancellata, from the mint family, is a plant that has antioxidant properties. In the present study, the hepatoprotective effect of Phlomis cancellata hydroalcoholic extract on acetaminophen-induced hepatotoxicity in rats wa...

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Ethanol-induced hepatotoxicity in male wistar rats: Effects of aqueous leaf extract of Ocimum gratissimum

Ocimum gratissimum leaf is commonly consumed as a spice and sometimes used in folklore medicine in Nigeria and other parts of the world. It has been reported to be rich in natural antioxidants such as flavonoids. The present study sought to evaluate the protective effects of its orally administered aqueous extract (0.2g/kg bwt/day and 0.4g/kg bwt/day for 35 days) on ethanol–induced oxidative st...

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ژورنال

عنوان ژورنال: Pharmaceutical Biology

سال: 2017

ISSN: 1388-0209,1744-5116

DOI: 10.1080/13880209.2017.1331248